circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: hsa-miR-93-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: Acute kidney injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human renal proximal tubular epithelial cell line (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF9
Associated microRNA: hsa-miR-93-5p
Biological function: Silencing of circHIPK3 improved cell apoptosis, oxidative stress, and inflammation in H/R-treated HK-2 cells.
Molecular mechanism: circHIPK3 initiated the reduction of miR-93-5p expression and sponged to miR-93-5p.
Survival: -
Supported No.:
 2
Description:

In conclusion, circHIPK3 knockdown alleviated oxidative stress and apoptosis and inhibited inflammation in AKI via miR-93-5p-mediated downregulation of the KLF9 signal pathway.
Other information
Title:

Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.

Journal: Comput Math Methods Med
Published: 2023/2/28
PubMed ID: 36846202