circRNA basic information
circBase ID: -
Name: hsa_circ_METTL9
Synonym: circMETTL9
Host Gene: -
 
 
 
Disease basic information
DO ID:
 81292
DO name: traumatic brain injury
Disease details: traumatic brain injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: SND1, CCL2, CXCL1, CCL3, CXCL3, CXCL10
Associated microRNA: -
Biological function: circMETTL9 knockdown significantly attenuated neurological dysfunction, cognitive impairment, and nerve cell apoptosis induced by TBI
Molecular mechanism: CircMETTL9/SND1/CCL2/CXCL1/CCL3/CXCL3/CXCL10
Survival: -
Supported No.:
 1
Description:

Altogether, we are the first to propose that circMETTL9 is a master regulator of neuroinflammation following TBI, and thus a major contributor to neurodegeneration and neurological dysfunction.
Other information
Title:

Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.

Journal: J Neuroinflammation
Published: 2023/2/22
PubMed ID: 36803376