circRNA basic information
circBase ID: -
Name: -
Synonym: circ101491
Host Gene: hsa-miR-125b-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: glioma cell lines (U251, U118, U87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EDN1
Associated microRNA: hsa-miR-125b-5p
Biological function: circ101491 overexpression promoted viability, invasion and migration of glioma cells both in vivo and in vitro
Molecular mechanism: circ101491/hsa-miR-125b-5p/EDN1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In summary, hypoxia could promote circ101491 overexpression in glioma cell-derived exosomes, and circ101491/miR-125b-5p/EDN1 regulatory axis might be implicated in the malignant progression of glioma.
Other information
Title:

Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1.

Journal: Brain Res Bull
Published: 2023/2/17
PubMed ID: 36796652