circRNA basic information
circBase ID: -
Name: hsa_circ_FOXP1
Synonym: circFOXP1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: acute ischemic stroke
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: glioblastoma cells (A172)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: STAT3
Associated microRNA: -
Biological function: knockdown and overexpression of circFOXP1 promoted and inhibited apoptotic signaling, respectively, following oxygen-glucose deprivation/reperfusion (OGD/R) treatment in vitro. Adeno-associated virus (AAV)-mediated circFOXP1 overexpression attenuated neurological deficits and improved functional recovery after transient middle cerebral artery occlusion (tMCAO) treatment in vivo
Molecular mechanism: circFOXP1/STAT3 axis, apoptotic signaling
Survival: better
Supported No.:
 1
Description:

In summary, our study is the first to reveal that circFOXP1 alleviates brain injury after cerebral ischemia by regulating STAT3/apoptotic signaling, which provides a potentially novel therapeutic target for AIS.
Other information
Title:

CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling.

Journal: Transl Res
Published: 2023/2/15
PubMed ID: 36787831