circRNA basic information
circBase ID: hsa_circ_0000566
Name: hsa_circ_VRK1
Synonym: circ_0000566
Host Gene: hsa-miR-18a-5p
 
 
 
Disease basic information
DO ID:
 178
DO name: vascular disease
Disease details: microvascular endothelial cell injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human brain microvascular endothelial cells (HBMECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ACVR2B
Associated microRNA: hsa-miR-18a-5p
Biological function: OGD/R treatment promoted HBMECs apoptosis and inflammation and suppressed cell viability, which could be attenuated by silencing of circ_0000566
Molecular mechanism: circ_0000566/hsa-miR-18a-5p/ACVR2B axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0000566 sponged miR-18a-5p to regulate OGD/R-induced HBMECs injury via regulating ACVR2B expression.
Other information
Title:

Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis.

Journal: Metab Brain Dis
Published: 2023/2/14
PubMed ID: 36781583