circRNA basic information
circBase ID: hsa_circ_0000735
Name: hsa_circ_P2RX1
Synonym: circ_0000735
Host Gene: hsa-miR-153-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bronchial epithelial-like cells (HBE), NSCLC cell lines (H1299, A549), HEK-293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ITGB1
Associated microRNA: hsa-miR-153-3p
Biological function: Propofol treatment overtly decreased circ_0000735 expression in NSCLC cells and repressed NSCLC cell viability, proliferation, invasion, and facilitated NSCLC cell apoptosis, but these effects mediated by propofol were counteracted by circ_0000735 overexpression
Molecular mechanism: circ_0000735/hsa-miR-153-3p/ITGB1 axis, miRNA sponge
Survival: -
Supported No.:
 4
Description:

In conclusion, propofol restrained NSCLC growth by downregulating circ_0000735, which functioned as a miR-153-3p sponge and regulated ITGB1 expression via adsorbing miR-153-3p. This study provides evidence to support that propofol curbs NSCLC progression by regulating circRNA expression.
Other information
Title:

Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-beta1 expression in non-small cell lung cancer.

Journal: Open Med (Wars)
Published: 2023/2/11
PubMed ID: 36760719