circRNA basic information
circBase ID: hsa_circ_0009158
Name: hsa_circ_ASPH
Synonym: circASPH
Host Gene: hsa-miR-139-5p
 
 
 
Disease basic information
DO ID:
 409
DO name: liver disease
Disease details: hepatic fibrosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: a human immortalized HSC line (LX-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Notch1
Associated microRNA: hsa-miR-139-5p
Biological function: Downregulation of circASPH expression inhibited hepatic stellate cell (HSC) activation and proliferation, induced apoptosis, and attenuated mouse liver fibrogenic injury
Molecular mechanism: circASPH/hsa-miR-139-5p/Notch1 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Thus, downregulation of circASPH may suppress the activation of HSCs and HF through the circASPH/miR-139-5p/Notch1 axis. Our findings indicated that circASPH may be a potential biomarker for HF diagnosis and therapy.
Other information
Title:

Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis.

Journal: Biochem Pharmacol
Published: 2023/2/10
PubMed ID: 36758707