circRNA basic information
circBase ID: -
Name: hsa_circ_RACGAP1
Synonym: circRACGAP1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human NSCLC cell lines (A549, H1299, H1975, H460, PC-9), human bronchial epithelial cell line (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT3, RIF1, Sox2
Associated microRNA: -
Biological function: The stemness, metastasis, and epithelial mesenchymal transformation were repressed in circRACGAP1-depleted NSCLC cells
Molecular mechanism: circRACGAP1/SIRT3/RIF1, Wnt/beta-catenin pathway
Survival: poor
Supported No.:
 2
Description:

Our results uncover a novel regulatory mechanism of circRACGAP1 in NSCLC and identify circRACGAP1 as a promising therapeutic target.
Other information
Title:

circ_rac GTPase-Activating Protein 1 Facilitates Stemness and Metastasis of Non-Small Cell Lung Cancer via Polypyrimidine Tract-Binding Protein 1 Recruitment to Promote Sirtuin-3-Mediated Replication Timing Regulatory Factor 1 Deacetylation.

Journal: Lab Invest
Published: 2023/2/8
PubMed ID: 36748197