circRNA basic information
circBase ID: -
Name: hsa_circ_KRT14
Synonym: circKRT14
Host Gene: hsa-miR-1256
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: esophageal cancer cell lines (KYSE-150, KYSE-410, EC9706), human esophageal epithelial cell line (HET-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F3
Associated microRNA: hsa-miR-1256
Biological function: CircKRT14 silencing inhibited EC cell proliferation, migration, and invasion, but promoted EC cell apoptosis in vitro
Molecular mechanism: circKRT14/hsa-miR-1256/E2F3 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

These results uncovered that circKRT14 up-regulated the expression of E2F3 and promoted the malignant development of EC through sponging miR-1256.
Other information
Title:

CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer.

Journal: Hum Exp Toxicol
Published: 2023/2/5
PubMed ID: 36738282