circRNA basic information
circBase ID: hsa_circ_0003340
Name: hsa_circ_OGDH
Synonym: -
Host Gene: hsa-miR-874-3p
 
 
 
Disease basic information
DO ID:
 5041
DO name: esophageal cancer
Disease details: esophageal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Esophageal cancer cell lines (ECA109, EC9706), normal esophageal epithelium cell line (HET-1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ENAH
Associated microRNA: hsa-miR-874-3p
Biological function: Circ_0003340 knockdown inhibited cell proliferation, migration, invasion, glucose consumption, and lactate production and induced cell apoptosis in esophageal cancer cells. Moreover, circ_0003340 knockdown suppressed tumor growth in vivo. MiR-874-3p was reduced in esophageal cancer tissues and cells, and it was a molecular mediator of circ_0003340 function in esophageal cancer cells.
Molecular mechanism: circ_0003340/hsa-miR-874-3p/ENAH axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

The data demonstrated that circ_0003340 promoted the progression of esophageal cancer through miR-874-3p/ENAH axis, which might provide novel therapeutic targets for esophageal cancer intervention.
Other information
Title:

Circ_0003340 regulates the expression of ENAH to affect the development of esophageal cancer through miR-874-3p.

Journal: Thorac Cancer
Published: 2023/2/4
PubMed ID: 36737402