circRNA basic information
circBase ID: -
Name: hsa_circ_POLA2
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: -
Biological function: circ_POLA2 overexpression decreased PTEN accumulation, but PTEN overexpression failed to significantly affect circ_POLA2 expression.
Molecular mechanism: circ_POLA2/PTEN axis
Survival: -
Supported No.:
 1
Description:

Circ_POLA2 is overexpressed in MCL and might promote GBM cell apoptosis through downregulating PTEN.
Other information
Title:

CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma.

Journal: Anticancer Drugs
Published: 2023/2/3
PubMed ID: 36730613