circRNA basic information
circBase ID: -
Name: hsa_circ_SETDB1
Synonym: circSETDB1
Host Gene: hsa-miR-508-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ABCC1
Associated microRNA: hsa-miR-508-3p
Biological function: CircSETDB1 knockdown inhibited cell proliferation viability, half maximal inhibitory concentration value of Ptx, cell cycle progression, and induced cell apoptosis in Ptx-resistant ovarian cancer cells.
Molecular mechanism: circSETDB1/hsa-miR-508-3p/ABCC1 axis, miRNA sponge
Survival: -
Supported No.:
 3
Description:

In conclusion, circSETDB1 regulated Ptx resistance of ovarian cancer by targeting miR-508-3p/ ABCC1 axis.
Other information
Title:

CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression.

Journal: Anticancer Drugs
Published: 2023/2/3
PubMed ID: 36729852