circRNA basic information
circBase ID: hsa_circ_0001312
Name: -
Synonym: circ_0001312
Host Gene: hsa-miR-409-3p
 
 
 
Disease basic information
DO ID:
 1287
DO name: cardiovascular system disease
Disease details: cardiotoxicity
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Human AC16 cardiomyocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-409-3p
Biological function: the knockdown of circ_0001312 could reverse DOX-evoked cardiomyocyte injury
Molecular mechanism: circ_0001312 bound competitively to miR-409-3p to up-regulate HMGB1, which was a target of miR-409-3p.
Survival: -
Supported No.:
 1
Description:

circ_0001312 was secreted by exosomes and could be transmitted via exosomes.Circ_0001312 reversed the cytotoxic effects mediated by DOX on cardiomyocytes via the miR-409-3p/HMGB1 axis.
Other information
Title:

Circ_0001312 Silencing Suppresses Doxorubicin-Induced Cardiotoxicity via MiR-409-3p/HMGB1 Axis.

Journal: Int Heart J
Published: 2023/2/2
PubMed ID: 36725075