circRNA basic information
circBase ID: -
Name: hsa_circ_DLGAP4
Synonym: circDLGAP4
Host Gene: hsa-miR-320
 
 
 
Disease basic information
DO ID:
 2316
DO name: brain ischemia
Disease details: cerebral ischemia/reperfusion injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human umbilical cord mesenchymal stem cells (hUC-MSCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF5
Associated microRNA: hsa-miR-320
Biological function: Knockdown of circDLGAP4 in hUC-MSCs-Exos reversed the promoting effects of hUC-MSCs-Exos on cell viability, migration, and tube formation in H/R-treated HBMECs in vitro and also abolished the protective effects of hUC-MSCs-Exos on cerebrovascular injury in I/R rats.
Molecular mechanism: circDLGAP4/hsa-miR-320/KLF5 axis, miRNA sponge
Survival: -
Supported No.:
 2
Description:

hUC-MSCs-Exos-derived circDLGAP4 reduced cerebrovascular injury by regulating miR-320/KLF5 signaling. These results provide a stem cell-based approach to treat CIRI.
Other information
Title:

Human umbilical cord mesenchymal stem cells-derived exosomal circDLGAP4 promotes angiogenesis after cerebral ischemia-reperfusion injury by regulating miR-320/KLF5 axis.

Journal: FASEB J
Published: 2023/2/2
PubMed ID: 36723877