circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: AML cell line (THP-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: c-Myc, CXCR4
Associated microRNA: -
Biological function: Cell viability and migration were inhibited and apoptosis was increased when circPVT1 was knocked down in THP-1 cells.
Molecular mechanism: circPVT1/c-Myc/CXCR4 axis, miRNA sponge
Survival: poor
Supported No.:
 2
Description:

Our findings showed that circPVT1 was highly expressed in AML patients and was related to shorter OS and RFS. CircPVT1 may exert an oncogenic effect in THP-1 cells by stabilizing c-Myc protein expression and downstream target CXCR4 expression.

Other information
Title:

Circular RNA PVT1 Regulates Cell Proliferation, Migration, and Apoptosis by Stabilizing c-Myc and Downstream Target CXCR4 Expression in Acute Myeloid Leukemia.

Journal: Turk J Haematol
Published: 2023/2/1
PubMed ID: 36718632