circRNA basic information
circBase ID: -
Name: mmu_circ_SCMH1
Synonym: circSCMH1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: stroke
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: mouse brain endothelial cell line (bEnd.3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FTO, Plpp3
Associated microRNA: -
Biological function: we identify the role of circSCMH1 in promoting vascular repair in peri-infarct cortex of male mice and male monkeys after photothrombotic (PT) stroke, and attenuating the ischemia-induced m6A methylation in peri-infarct cortex of male mice after PT stroke.
Molecular mechanism: circSCMH/FTO/Plpp3 axis
Survival: -
Supported No.:
 1
Description:

Our data demonstrate that circSCMH1 enhances vascular repair via FTO-regulated m(6)A methylation after stroke, providing insights into the mechanism of circSCMH1 in promoting stroke recovery.
Other information
Title:

FTO-dependent m(6)A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.

Journal: Nat Commun
Published: 2023/1/31
PubMed ID: 36717587