circRNA basic information
circBase ID: hsa_circ_0020377
Name: hsa_circ_ADAM12
Synonym: -
Host Gene: hsa-miR-194-5p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human oral keratinocytes, OSCC cell lines (SCC-9, HSC-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF7
Associated microRNA: hsa-miR-194-5p
Biological function: Loss-of-function experiments proved that hsa_circ_0020377 depletion might block OSCC cell proliferation, cycle progression, migration, invasion, and glycolysis in vitro. In xenograft mouse models, hsa_circ_0020377 silencing might suppress tumor growth.
Molecular mechanism: hsa_circ_0020377/hsa-miR-194-5p/KLF7 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

These results broaden our insights regarding the regulation of OSCC progression via circRNA and act as a reference for future clinical studies in OSCC diagnosis and treatment.
Other information
Title:

Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression.

Journal: Funct Integr Genomics
Published: 2023/1/31
PubMed ID: 36717528