circRNA basic information
circBase ID: -
Name: mmu_circ_calm4
Synonym: circ-calm4
Host Gene: -
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: hypoxia-induced pulmonary artery smooth muscle autophagy
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Purb, Beclin1
Associated microRNA: -
Biological function: Knockdown of circ-calm4 both in vivo and in vitro can inhibit the autophagy in PASMCs induced by hypoxia.
Molecular mechanism: circ-calm4/Purb/Beclin1 axis
Survival: -
Supported No.:
 1
Description:

Overall, our results confirm that the circ-calm4/Purb/Beclin1 signal axis is involved in the occurrence of hypoxia-induced PASMCs autophagy, and the novel regulatory mechanisms and signals transduction pathways in PASMC autophagy induced by hypoxia.
Other information
Title:

Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb.

Journal: J Mol Cell Cardiol
Published: 2023/1/31
PubMed ID: 36716953