circRNA basic information
circBase ID: hsa_circ_0006667
Name: -
Synonym: circ_0006667
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: Diabetic retinopathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: ARPE-19 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGFA
Associated microRNA: hsa-miR-7-5p
Biological function: Circ_0006667 expression was up-regulated in DR patients and HG-induced ARPE-19 cells. HG stimulation suppressed ARPE-19 cell proliferation and promoted cell apoptosis and inflammation, which were alleviated via circ_0006667 silence.
Molecular mechanism: Circ_0006667 acted as a molecular sponge for miR-7-5p, and circ_0006667 absence-mediated protective effects in HG-induced ARPE-19 cells were largely overturned by the interference of miR-7-5p. miR-7-5p directly targeted TGFA, and miR-7-5p overexpression protected ARPE-19 cells from HG-induced dysfunction largely by down-regulating TGFA.
Survival: -
Supported No.:
 1
Description:

Circ_0006667 silencing protected ARPE-19 cells from HG-induced dysfunction by mediating miR-7-5p/TGFA axis.
Other information
Title:

Circ_0006667 contributes to high glucose-induced retinal pigment epithelial cell dysfunction by mediating miR-7-5p/TGFA axis in diabetic retinopathy.

Journal: Int Ophthalmol
Published: 2023/1/31
PubMed ID: 36715959