circRNA basic information
circBase ID: hsa_circ_0001498
Name: -
Synonym: circ_0001498
Host Gene: hsa-miR-574-5p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: WI-38 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX6
Associated microRNA: hsa-miR-574-5p
Biological function: Silencing circ_0001498 reduced LPS-induced cell apoptosis and inflammation.
Molecular mechanism: Circ_0001498 interacted with miR-574-5p. The regulation of circ_0001498 knockdown was abolished by miR-574-5p inhibitor. Furthermore, miR-574-5p directly targeted SOX6 and circ_0001498 upregulated SOX6 via targeting miR-574-5p.
Survival: -
Supported No.:
 1
Description:

This research identified that circ_0001498 facilitated sepsis-related ALI progression by targeting miR-574-5p to upregulate SOX6.
Other information
Title:

Circ_0001498 contributes to lipopolysaccharide-induced lung cell apoptosis and inflammation in sepsis-related acute lung injury via upregulating SOX6 by interacting with miR-574-5p.

Journal: Gen Physiol Biophys
Published: 2023/1/28
PubMed ID: 36705303