circRNA basic information
circBase ID: -
Name: hsa_circ_NLRP3
Synonym: circNLRP3
Host Gene: hsa-miR-221-5p
 
 
 
Disease basic information
DO ID:
 0050117
DO name: disease by infectious agent
Disease details: Inflammation
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: mouse macrophage cell (RAW264.7)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: A20
Associated microRNA: hsa-miR-221-5p
Biological function: -
Molecular mechanism: circNLRP3/miR-221-5p/A20 axis, miRNA sponge, NF-kB signaling pathway
Survival: -
Supported No.:
 1
Description:

Our findings elucidated a possible mechanistic link between the circNLRP3/miR-221-5p/A20 axis and RT-induced inflammatory response, which may broaden our understanding of RT poisoning.
Other information
Title:

A novel circular RNA circNLRP3 alleviated ricin toxin-induced TNF-alpha production through sponging miR-221-5p.

Journal: Toxicon
Published: 2023/1/27
PubMed ID: 36702354