circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: circ-FADS2, hsa_circRNA_100833
Host Gene: hsa-miR-498
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC lines (SW480, SW620, HCT116, HT29), normal human colon cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: S100A16
Associated microRNA: hsa-miR-498
Biological function: silencing circ-FADS2 markedly inhibited the proliferation and invasion of CRC and increased the percentage of cancer cells in the G1 phase in vitro
Molecular mechanism: circ-FADS2/hsa-miR-498/S100A16/AKT signaling, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

A study of the molecular mechanism suggests that a circ-FADS2/miR-498/S100A16/AKT signaling cascade may be a potential therapeutic target for the treatment of CRC.
Other information
Title:

Circular ribonucleic acid circ-FADS2 promotes colorectal cancer cell proliferation and invasion by regulating miR-498/S100A16.

Journal: J Physiol Pharmacol
Published: 2023/1/26
PubMed ID: 36696241