circRNA basic information
circBase ID: hsa_circ_0070659
Name: hsa_circ_CCDC109B
Synonym: -
Host Gene: hsa-miR-377
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lung cancer cell lines (A549, PC9, H460, H82, H1650, H1299), human normal bronchial epithelial cell lines (16HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: RAB3C
Associated microRNA: hsa-miR-377
Biological function: NSCLC cell proliferation, migration, and invasion abilities after circ_0070659 silencing was detected by colony formation assay, Cell Counting Kit-8 (CCK-8) assay and Transwell assay.
Molecular mechanism: circ_0070659/hsa-miR-377/RAB3C axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our study revealed a novel signaling pathway that circ_0070659/miR-377/RAB3C axis regulates tumor progression, and it may become a new therapeutic target for NSCLC.
Other information
Title:

CircRNA hsa_circ_0070659 predicts poor prognosis and promotes non-small cell lung cancer (NSCLC) progression via microRNA-377 (miR-377) / Ras-Associated Binding Protein 3C (RAB3C) pathway.

Journal: Bioengineered
Published: 2023/1/26
PubMed ID: 36694911