circRNA basic information
circBase ID: -
Name: cel_circ_zip-2
Synonym: circzip-2
Host Gene: cel-miR-60
 
 
 
Disease basic information
DO ID:
 14330
DO name: Parkinson disease
Disease details: Parkinson disease
Species: others
Species details: C. elegans
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Daf-16
Associated microRNA: cel-miR-60
Biological function: Studying RNAi-induced knockdown conditions of zip-2, we observed a reduced aggregation of alpha-synuclein protein along with an enhanced lifespan of the worms.
Molecular mechanism: circzip-2/miR-60 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Further interaction studies revealed that circzip-2 possibly sponges microRNA molecule miR-60 towards asserting an important role in various processes associated with PD.
Other information
Title:

Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson Disease.

Journal: Mol Neurobiol
Published: 2018/1/25
PubMed ID: 29363043