circRNA basic information
circBase ID: -
Name: mmu_circ_Uxs1
Synonym: circUxs1
Host Gene: mmu-miR-335-5p
 
 
 
Disease basic information
DO ID:
 11382
DO name: corneal neovascularization
Disease details: choroidal neovascularization
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PGF
Associated microRNA: mmu-miR-335-5p
Biological function: Knockdown of circRNA Uxs1 interrupted the tube formation, migration, and proliferation of endothelial cells in vitro. Silencing circRNA Uxs1 in vivo alleviated neovascularization formation, as shown by the decreased size of laser spots.
Molecular mechanism: circUxs1/mmu-miR-335-5p/PGF axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circRNA Uxs1 promoted CNV by sponging miR-335-5p, which stimulated PGF expression and subsequently activated the mTOR/p70 S6k pathway. Therefore, circRNA Uxs1 may serve as a promising therapeutic target for CNV.
Other information
Title:

CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway.

Journal: Transl Res
Published: 2023/1/24
PubMed ID: 36690073