circRNA basic information
circBase ID: hsa_circ_0002346
Name: hsa_circ_CRIM1
Synonym: circCRIM1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NSCLC cell lines (A549, H1299, Calu1), human bronchial epithelial cell line (BEAS-2B), murine lung carcinoma cell line (LLC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: IGF2BP1, HLA-F
Associated microRNA: -
Biological function: the overexpression of circCRIM1 suppressed the immune evasion of NSCLC and promoted the expressions of Granzyme B, IFN-gamma, and TNF-alpha of CD8+ T and NK cell in vitro co-culture assays and tumor xenograft models.
Molecular mechanism: circCRIM1/IGF2BP1/HLA-F axis
Survival: -
Supported No.:
 2
Description:

This study identifies circCRIM1 as a new tumor suppressor that inhibits tumor immune evasion through a competitive combination with IGF2BP1 to destabilize HLA-F mRNA.
Other information
Title:

Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion.

Journal: Cells
Published: 2023/1/22
PubMed ID: 36672208