circRNA basic information
circBase ID: hsa_circ_0075323
Name: hsa_circ_QSTM1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human astrocytes (HEB), human glioblastoma cell lines (U87-MG, U251-MG, A172, T98G)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: p62, LC3B
Associated microRNA: -
Biological function: Inhibition of hsa_circ_0075323 in U87-MG and T98G cells attenuated proliferation and invasion ability significantly, while upregulation of has_ circ_0075323 enhanced proliferation and migration of U251-MG and A172 cells.
Molecular mechanism: hsa_circ_0075323/p62/LC3B axis
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0075323 regulates p62-mediated autophagy pathway to promote GBM progression and may serve as a prognostic biomarker potentially.
Other information
Title:

Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy.

Journal: Cell Div
Published: 2023/1/18
PubMed ID: 36650519