circRNA basic information
circBase ID: -
Name: mmu_circ_LPAR1
Synonym: circLPAR1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 231
DO name: motor neuron disease
Disease details: neuroinflammation
Species: mouse
Species details: mouse
Sample type: tissue, cell line
Sample type details: SH-SY5Y cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GDF-15, UPF1
Associated microRNA: -
Biological function: Knockdown of circLPAR1 and overexpression of GDF-15 protected cells against Abeta-caused inflammation, oxidative stress, and neuronal apoptosis. CircLPAR1 knockdown was also proved to improve AD-related pathological traits and ameliorate cognitive dysfunctions in vivo.
Molecular mechanism: circLPAR1/GDF-15/UPF1 axis,
Survival: -
Supported No.:
 1
Description:

Herein, UPF1 was predicted to have binding sites on both circLPAR1 and GDF-15 using starBase (version 3.0); therefore, we speculated that circLPAR1 might regulate the expression of GDF-15 through the interaction with UPF1, thus participating in AD pathogenesis.
Other information
Title:

CircLPAR1 Promotes Neuroinflammation and Oxidative Stress in APP/PS1 Mice by Inhibiting SIRT1/Nrf-2/HO-1 Axis Through Destabilizing GDF-15 mRNA.

Journal: Mol Neurobiol
Published: 2023/1/17
PubMed ID: 36646968