circRNA basic information
circBase ID: hsa_circ_0097010
Name: -
Synonym: circ_0097010
Host Gene: hsa-miR-769-5p
 
 
 
Disease basic information
DO ID:
 824
DO name: periodontitis
Disease details: Periodontitis
Species: human
Species details: human
Sample type: cell line
Sample type details: Human periodontal ligament cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: KLF6
Associated microRNA: hsa-miR-769-5p
Biological function: Circ_0097010 was upregulated in periodontitis samples and LPS-exposed hPDLCs. Downregulation of circ_0097010 exerted anti-apoptosis and anti-inflammation functions in LPS-exposed hPDLCs.
Molecular mechanism: circ_0097010 acted as a miR-769-5p sponge, and reduced abundance of miR-769-5p reversed the anti-apoptosis and anti-inflammation effects of circ_0097010 suppression. KLF6 was a direct miR-769-5p target, and miR-769-5p-mediated inhibition of KLF6 possessed anti-apoptosis and anti-inflammation functions in LPS-induced hPDLCs. Moreover, circ_0097010 controlled KLF6 expression by miR-769-5p.
Survival: -
Supported No.:
 1
Description:

These data identify circ_0097010 as a key regulator of LPS-induced inflammation and apoptosis in hPDLCs and highlight a novel mechanism of circ_0097010 regulation through miR-769-5p/KLF6 axis.
Other information
Title:

Anti-apoptosis and anti-inflammation activity of circ_0097010 downregulation in lipopolysaccharide-stimulated periodontal ligament cells by miR-769-5p/Kruppel like factor 6 axis.

Journal: J Dent Sci
Published: 2023/1/17
PubMed ID: 36643256