circRNA basic information
circBase ID: hsa_circ_0031584
Name: hsa_circ_ARHGAP5
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3744
DO name: cervical squamous cell carcinoma
Disease details: cervical squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cervical cancer SiHa, HeLa, ME-180 cells (ATCC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: AUF1, BIM
Associated microRNA: -
Biological function: experiments from overexpression/knockdown cell lines revealed that circARHGAP5 could inhibit cisplatin-mediated cell apoptosis in CSCC cells both in vitro and in vivo.
Molecular mechanism: circARHGAP5/AUF1/BIM axis
Survival: -
Supported No.:
 1
Description:

Collectively, our data indicated that circARHGAP5 directly bound to AUF1 and prevented AUF1 from interacting with BIM mRNA, thereby playing a pivotal role in cisplatin resistance in CSCC. Our study provides insights into overcoming cancer resistance to cisplatin treatment.
Other information
Title:

Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.

Journal: Cancer Sci
Published: 2023/1/13
PubMed ID: 36632741