circRNA basic information
circBase ID: hsa_circ_0006404
Name: hsa_circ_FOXO3
Synonym: -
Host Gene: hsa-miR-29a-3p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: EC (Ishikawa, HEC-1A, HEC-1B, HEC-251, RL95-2), human endometrial stromal cell lines (T-HESC)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HDAC4
Associated microRNA: hsa-miR-29a-3p
Biological function: suppressing circ_FOXO3 expression abrogated EC by regulating cell proliferation, apoptosis, migration, and invasion
Molecular mechanism: circ_FOXO3/hsa-miR-29a-3p/HDAC4 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_FOXO3 promotes EC progression by sponging miR-29a-3p and upregulating HDAC4, making it a promising therapeutic target in EC.
Other information
Title:

Circular RNA FOXO3 regulates endometrial carcinoma progression through the microRNA-29a-3p/HDAC4 axis.

Journal: Am J Transl Res
Published: 2023/1/12
PubMed ID: 36628205