circRNA basic information
circBase ID: hsa_circ_0000519
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-1296
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (SNU-387, Hep3B, Huh7, MHCC97L), human hepatic cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: E2F7
Associated microRNA: hsa-miR-1296
Biological function: Knockdown of hsa_circ_0000519 significantly reduced HCC cell viability, suppressed cell proliferation, and induced cell cycle arrest in G0/G1. Downregulation of hsa_circ_0000519 also inhibited formation of capillary-like endothelial structures in vitro and impeded microvessel formation in mice bearing HCC tumors. The migration and invasive capacities of HCC cells were markedly reduced by hsa_circ_0000519 knockdown.
Molecular mechanism: hsa_circ_0000519/hsa-miR-1296/E2F7 axis, miRNA sponge
Survival: poor
Supported No.:
 6
Description:

These data suggest the potential clinical application of hsa_circ_0000519 in HCC treatment.
Other information
Title:

Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.

Journal: Hum Cell
Published: 2023/1/11
PubMed ID: 36627545