circRNA basic information
circBase ID: -
Name: hsa_circ_SESN2
Synonym: circSESN2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 11714
DO name: gestational diabetes
Disease details: Gestational diabetes mellitus
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human chorionic trophoblast cells (HTR-8/SVneo cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF2BP2
Associated microRNA: -
Biological function: suppressing circSESN2 or IGF2BP2 increased HTR-8/SVneo cell invasion and migration, decreased cell apoptosis, and reduced pro-inflammatory cytokine release and oxidative stress injury.
Molecular mechanism: CircSESN2/IGF2BP2
Survival: -
Supported No.:
 1
Description:

Collectively, circSESN2 exacerbated HG-induced trophoblast cell damage by binding IGF2BP2 and upregulating its protein expression.
Other information
Title:

Circular RNA SESN2 aggravates gestational trophoblast cell damage induced by high glucose by binding to IGF2BP2.

Journal: Mol Reprod Dev
Published: 2023/1/10
PubMed ID: 36623264