circRNA basic information
circBase ID: -
Name: hsa_circ_SNX12
Synonym: circSnx12
Host Gene: hsa-miR-194-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SLC7A11
Associated microRNA: hsa-miR-194-5p
Biological function: Knockdown of circSnx12 rendered cisplatin-resistant OC cells more sensitive to cisplatin in vitro and in vivo by activating ferroptosis, which was at least partially abolished by downregulation of miR-194-5p.
Molecular mechanism: hsa-miR-194-5p/SLC7A11
Survival: -
Supported No.:
 1
Description:

CircARNT2 may thus serve as an effective therapeutic target for overcoming cisplatin resistance in OC.
Other information
Title:

circRNA circSnx12 confers Cisplatin chemoresistance to ovarian cancer by inhibiting ferroptosis through a miR-194-5p/SLC7A11 axis.

Journal: BMB Rep
Published: 2023/1/9
PubMed ID: 36617466