circRNA basic information
circBase ID: hsa_circ_0001721
Name: -
Synonym: circ_0001721
Host Gene: hsa-miR-373-3p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: mimic OA cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCR4
Associated microRNA: hsa-miR-373-3p
Biological function: Knockdown of circ_0001721 alleviated IL-1beta-induced chondrocyte injury.
Molecular mechanism: MiR-373-3p could be sponged by circ_0001721, and its inhibitor reversed the regulation of circ_0001721 knockdown on IL-1beta-induced chondrocyte injury. CXCR4 was a target of miR-373-3p, and circ_0001721 could sponge miR-373-3p to regulate CXCR4. Furthermore, miR-373-3p overexpression inhibited IL-1beta-induced chondrocyte injury, and these effects could be overturned by CXCR4 upregulation.
Survival: -
Supported No.:
 1
Description:

Our data confirmed that circ_0001721 knockdown alleviated IL-1beta-induced chondrocyte injury by miR-373-3p/CXCR4 axis, which suggested that circ_0001721 might be a potential therapeutic target for OA.
Other information
Title:

Circ_0001721 knockdown relieves IL-1beta-induced chondrocyte injury via regulating miR-373-3p/CXCR4 in osteoarthritis.

Journal: Int Immunopharmacol
Published: 2023/1/7
PubMed ID: 36608447