circRNA basic information
circBase ID: -
Name: hsa_circ_FGFR1
Synonym: -
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PIK3CB
Associated microRNA: hsa-miR-532-3p
Biological function: knockdown of circFGFR1 restrained in vitro PDAC cell growth, migration, invasion, and in vivo xenograft tumor growth and lung metastasis.
Molecular mechanism: circFGFR1/hsa-miR-532-3p/PIK3CB axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our data revealed that circFGFR1 driven the malignant progression of PDAC by targeting miR-532-3p/PIK3CB axis, suggesting that inhibition of circFGFR1 might be considered as a therapeutic target for PDAC.
Other information
Title:

Circular RNA Fibroblast Growth Factor Receptor 1 Promotes Pancreatic Cancer Progression by Targeting MicroRNA-532-3p/PIK3CB Axis.

Journal: Pancreas
Published: 2023/1/7
PubMed ID: 36607937