circRNA basic information
circBase ID: hsa_circ_0114428
Name: hsa_circ_ZNF644
Synonym: circ_0114428
Host Gene: hsa-miR-370-3p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: septic acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TIMP2
Associated microRNA: hsa-miR-370-3p
Biological function: The knockdown of circ_0114428 notably promoted cell proliferation and cycle, whereas it restrained cell inflammation and apoptosis in LPS-stimulated HK2 cells.
Molecular mechanism: circ_0114428/hsa-miR-370-3p/TIMP2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Our data demonstrated that circ_0114428 contributed to septic AKI progression by regulating miR-370-3p-mediated TIMP2 expression, which provided a promising target for septic AKI treatment.
Other information
Title:

Circ_0114428 Influences the Progression of Septic Acute Kidney Injury Via Regulating Mir-370-3p/Timp2 Axis.

Journal: Shock
Published: 2023/1/5
PubMed ID: 36597773