circRNA basic information
circBase ID: -
Name: hsa_circ_VAPA
Synonym: circVAPA
Host Gene: hsa-miR-125b-5p
 
 
 
Disease basic information
DO ID:
 8893
DO name: psoriasis
Disease details: psoriasis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human immortalized keratinocyte cell lines (HaCaT)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SIRT6
Associated microRNA: hsa-miR-125b-5p
Biological function: circVAPA knockdown significantly suppressed the promotion of M5 on cell viability, proliferation, and inflammation of HaCaT cells
Molecular mechanism: circVAPA/hsa-miR-125b-5p/sirt6 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

CircVAPA participate in the progression of psoriasis through miR-125b-5p/sirt6 axis by regulating proliferation and inflammation of keratinocytes, highlighting a potential therapeutic target for psoriasis.
Other information
Title:

CircVAPA contributes to hyper-proliferation and inflammation of keratinocytes through miR-125b-5p/sirt6 axis in psoriasis.

Journal: Int Immunopharmacol
Published: 2023/1/3
PubMed ID: 36592530