circRNA basic information
circBase ID: -
Name: -
Synonym: rno-circRNA-013017
Host Gene: rno-miR-16-5p
 
 
 
Disease basic information
DO ID:
 319
DO name: spinal cord disease
Disease details: traumatic spinal cord injury
Species: rat
Species details: rat
Sample type: tissue
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: bcl-2
Associated microRNA: rno-miR-16-5p
Biological function: rno-circRNA-013017 inhibited descending axonal degeneration and preserved motor neurons and descending axons at 6 weeks post-SCI using immunofluorescence, biotin dextran amine diffusion tensor imaging. the overexpression of rno-circRNA-013017 promoted the locomotor function of rats after SCI using open-field test and gait analysis.
Molecular mechanism: rno_circRNA_013017/rno-miR-16-5p/bcl-2 axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

our future work will include rescue experiments on rno-circRNA-013017 and its target genes to verify their relationship in vitro and in vivo. Namely, we will verify the rno_circRNA_013017/rno-miR-16-5p/bcl-2 pathway in cell lines and then perform the animal experiments.
Other information
Title:

Inhibition by rno-circRNA-013017 of the apoptosis of motor neurons in anterior horn and descending axonal degeneration in rats after traumatic spinal cord injury.

Journal: Front Neurosci
Published: 2023/1/3
PubMed ID: 36590290