circRNA basic information
circBase ID: hsa_circ_0008003
Name: hsa_circ_LDB2
Synonym: -
Host Gene: hsa-miR-548I
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: bronchial epithelial cell line (16HBE), NSCLC cell lines (H1299, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GOT2
Associated microRNA: hsa-miR-548I
Biological function: Circ_0008003 knockdown reduced cell viability, migration, invasion, angiogenesis, and caused apoptosis in NSCLC cells.
Molecular mechanism: hsa_circ_0008003/hsa-miR-548I/KPNA4 axis, miRNA sponge
Survival: poor
Supported No.:
 4
Description:

Circular RNA hsa_circ_0008003 promoted progression in NSCLC by sponging miR-548I and regulating KPNA4 expression, hinting that circ_0008003 participates in NSCLC pathogenesis.
Other information
Title:

Circular RNA hsa_circ_0008003 promotes the progression of non-small-cell lung cancer by sponging miR-548I and regulating KPNA4 expression.

Journal: Thorac Cancer
Published: 2022/12/28
PubMed ID: 36573325