circRNA basic information
circBase ID: -
Name: hsa_circ_MGEA5
Synonym: circMGEA5
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OS cells U2OS, MG63 cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: -
Biological function: Knockdown of circMGEA5 suppressed OS cell migration, invasion, and epithelial-mesenchymal transition (EMT)
Molecular mechanism: circMGEA5/hsa-miR-153-3p/hsa-miR-8084/ZEB1 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

In sum, our findings, for the first time, reveal the metastasis-promoting role of circMGEA5 in OS. Targeting of this newly identified ceRNA axis may be crucial in the development of novel therapies for metastatic OS patients.
Other information
Title:

Circular RNA expression profile identifies circMGEA5 as a novel metastasis-promoting factor and potential biomarker in osteosarcoma.

Journal: J Biochem Mol Toxicol
Published: 2022/12/25
PubMed ID: 36564929