circRNA basic information
circBase ID: hsa_circ_0092887
Name: hsa_circ_DHTKD1
Synonym: circ_0092887
Host Gene: hsa-miR-490-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MRC5
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: UBE2T
Associated microRNA: hsa-miR-490-5p
Biological function: Silencing of hsa_circ_0092887 in PTX-treated NSCLC cells inhibited cell proliferation and migration, induced apoptosis, and suppressed tumor growth in xenograft mouse models in vivo.
Molecular mechanism: hsa_circ_0092887hsa-miR-490-5p/UBE2T axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0092887 depletion alleviated PTX-resistance in NSCLC cells via modulating the miR-490-5p/UBE2T axis, and the targeted management of hsa_circ_0092887-mediated signaling axis might contribute to PTX-resistance intervention in NSCLC.
Other information
Title:

Hsa_circ_0092887 targeting miR-490-5p/UBE2T promotes paclitaxel resistance in non-small cell lung cancer.

Journal: J Clin Lab Anal
Published: 2022/12/23
PubMed ID: 36550019