circRNA basic information
circBase ID: -
Name: hsa_circ_ZEB1
Synonym: circ-ZEB1
Host Gene: hsa-miR-200c-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SW480, RKO
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-200c-5p
Biological function: Downregulation of circ-ZEB1 inhibited cell proliferation, colony formation, as well as cell migration and invasion abilities of CRC cell lines. In vivo experiments indicated that knockdown of circ-ZEB1 suppressed tumorigenesis and distant metastasis of CRC cells in nude mice.
Molecular mechanism: circ-ZEB1/hsa-miR-200c/EMT axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

In conclusion, circ-ZEB1 could promote CRC cells progression, EMT, and chemoresistance via acting on miR-200c, elucidating a potential therapeutic target to inhibit CRC progression.

Other information
Title:

circ-ZEB1 regulates epithelial-mesenchymal transition and chemotherapy resistance of colorectal cancer through acting on miR-200c-5p.

Journal: Transl Oncol
Published: 2022/12/22
PubMed ID: 36542990