circRNA basic information
circBase ID: -
Name: hsa_circ_IGF1R
Synonym: Circ-IGF1R
Host Gene: hsa-miR-362-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NCM460, SW480, LOVO, SW620, HT29
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB3
Associated microRNA: hsa-miR-362-5p
Biological function: Knockdown of circ-IGF1R inhibited proliferation, migration, invasion and glycolysis but induced apoptosis of CRC cells.
Molecular mechanism: Wnt/beta-Catenin Signal Pathway
Survival: -
Supported No.:
 1
Description:

This study hypothesized that circ-IGF1R sponged miR-362-5p to regulate HMGB3 level and activate HMGB3/Wnt/beta-catenin pathway in CRC cell development.
Other information
Title:

Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/beta-Catenin Signal Pathway.

Journal: Biochem Genet
Published: 2022/12/22
PubMed ID: 36542208