circRNA basic information
circBase ID: -
Name: hsa_circ_NT5C2
Synonym: circ-NT5C2
Host Gene: hsa-miR-142-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CHON-001
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NAMPT
Associated microRNA: hsa-miR-142-5p
Biological function: Circ-NT5C2 silencing alleviated IL-1beta-induced inhibitory effects on chondrocyte proliferation and ECM generation, meanwhile the promotional role of IL-1beta on chondrocyte apoptosis and inflammation was also weakened.
Molecular mechanism: circ-NT5C2/hsa-miR-142-5p/NAMPT axis, miRNA sponge
Survival: -
Supported No.:
 1
Description:

Collectively, circ-NT5C2 accelerated the OA process by targeting the miR-142-5p/NAMPT axis. This study provides valuable information to find a better treatment for OA.
Other information
Title:

Silencing of circ-NT5C2 retards the progression of IL-1beta-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.

Journal: Microbiol Immunol
Published: 2022/12/22
PubMed ID: 36540014