circRNA basic information
circBase ID: -
Name: hsa_circ_ABCC
Synonym: Circ-ABCC4
Host Gene: hsa-miR-1253
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: DU145, PC3, VCaP, 22Rv1, RWPE-1
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: hsa-miR-1253
Biological function: Circ-ABCC4 depletion blocked PCa cell viability, proliferation, invasion, and radioresistance and triggered apoptosis.
Molecular mechanism: Circ-ABCC4/hsa-miR-1253/SOX4 axis, miRNA sponge
Survival: poor
Supported No.:
 1
Description:

Circ-ABCC4 could enhance SOX4 abundance by absorbing miR-1253. Circ-ABCC4 exerted a pro-tumor activity by facilitating PCa cell viability, proliferation, invasion, and radioresistance and suppressing apoptosis.
Other information
Title:

Circ-ABCC4 contributes to prostate cancer progression and radioresistance by mediating miR-1253/SOX4 cascade.

Journal: Anticancer Drugs
Published: 2022/12/21
PubMed ID: 36539368