circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circ-ITCH
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10881
DO name: hand, foot and mouth disease
Disease details: diabetic foot ulcer
Species: human
Species details: human
Sample type: cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: TAF15, Nrf2
Associated microRNA: -
Biological function: alleviate HG-induced ferroptosis and improve the angiogenesis ability of HUVECs
Molecular mechanism: Nrf2 signalling pathway
Survival: -
Supported No.:
 1
Description:

Exosomal circ-ITCH from BMSCs inhibited ferroptosis and improved the angiogenesis of HUVECs through activation of the Nrf2 signalling pathway by recruiting TAF15 protein, ultimately accelerating the wound healing process in DFU.
Other information
Title:

Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis.

Journal: Diabet Med
Published: 2022/12/21
PubMed ID: 36537855