circRNA basic information
circBase ID: hsa_circ_0000277
Name: hsa_circ_PDE3B
Synonym: -
Host Gene: hsa-miR-136-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HET-1A, EC9706, KYSE30
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: MAP3K2
Associated microRNA: hsa-miR-136-5p
Biological function: promote cell proliferation, migration and invasion
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

In conclusion, circ_PDE3B acted as oncogenic circRNA in ESCC and accelerated ESCC progression by adsorption of miR-136-5p and activation of MAP3K2, supporting circ_PDE3B as a potential therapeutic target for ESCC.
Other information
Title:

CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma.

Journal: Histol Histopathol
Published: 2022/12/20
PubMed ID: 36533720