circRNA basic information
circBase ID: -
Name: hsa_circ_CCS
Synonym: Circ-CCS
Host Gene: hsa-miR-874-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: LoVo, SW620, SW480, HCT-116, NCM460
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: HK2
Associated microRNA: hsa-miR-874-3p
Biological function: Circ-CCS increased cell proliferation, migration, invasion and glycolysis metabolism, decreased cell apoptosis
Molecular mechanism: circ-CCS/hsa-miR-874-3p/HK2 axis
Survival: -
Supported No.:
 1
Description:

The results also showed that HK2 could regulate the development of CRC. In mechanism, circ-CCS targeted miR-874-3p to control HK2. In addition, circ-CCS knock-down also attenuated tumor growth in mice.
Other information
Title:

Circ-CCS regulates oxaliplatin resistance via targeting miR-874-3p/HK2 axis in colorectal cancer.

Journal: Histol Histopathol
Published: 2022/12/16
PubMed ID: 36519522