circRNA basic information
circBase ID: hsa_circ_0045462
Name: hsa_circ_BPTF
Synonym: circ-BPTF
Host Gene: hsa-miR-486-5p
 
 
 
Disease basic information
DO ID:
 3083
DO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: hPASMC
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CEMIP
Associated microRNA: hsa-miR-486-5p
Biological function: promotes hPASMC proliferation
Molecular mechanism: circ-BPTF/hsa-miR-486-5p/CEMIP axis
Survival: -
Supported No.:
 1
Description:

Overall, our study shows that circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promote hypoxic PASMC proliferation in pulmonary vascular remodelling in COPD.
Other information
Title:

circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD.

Journal: Acta Biochim Biophys Sin (Shanghai)
Published: 2022/12/15
PubMed ID: 36514216